GEN2 “T"
A 39-amino-acid, acylated dual incretin analog that activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors in in-vitro GPCR pharmacology. Lipidation via a long-chain diacid linker enhances albumin association and peptide persistence in cell-based systems. Supplied at ≥ 99% purity (HPLC/MS verified) for in-vitro, cellular, and biochemical research use only (RUO). Not for human or veterinary use.
Specifications
| CAS Number | 2023788-19-2 |
| Chemical Name | Dual GIP/GLP-1 receptor agonist peptide |
| PubChem CID | 156588324 |
| Molecular Formula | C225H348N48O68 (free base) |
| Molecular Weight | ≈ 4,813.5 g/mol (free base) |
| Sequence | 39-aa dual incretin analog with Aib substitutions at positions 2 and 13; Lys20 acylated via γ-Glu–(AEEA)2–C20 fatty diacid; C-terminal amide; linear (no disulfides). Exact lot details: see COA. |
| Counter-ion | Acetate (typical; confirm on lot COA) |
| Physical Appearance | White to off-white lyophilized powder |
| Container | 3 mL Type I glass vial, bromobutyl rubber stopper, aluminum flip-off seal (net content: 50 mg) |
| Purity | ≥ 99% (verified by HPLC & MS; third-party tested) |
Potential Applications in Research
Strictly in-vitro, cellular, or biochemical contexts — no clinical or human-use claims.
- GIPR/GLP-1R pharmacology: cAMP accumulation, β-arrestin recruitment, and receptor internalization in engineered cell systems.
- Biased signaling & pathway profiling: Quantify relative bias vs. selective GLP-1R or GIPR agonists.
- Ligand binding/occupancy: Competition and kinetic studies against mono-agonist comparators.
- Receptor cross-talk: Explore co-expressed GLP-1R/GIPR pathway integration and downstream transcriptional signatures.
- Formulation/stability: Assess adsorption, aggregation resistance, and excipient impacts under cell-culture conditions.
Compliance & RUO Disclaimer
For laboratory research use only (RUO). Not a drug, food, or cosmetic. Not for human or veterinary use. Purchase and use are limited to qualified personnel operating under institutional laboratory guidelines.